Strain Development

Development of E.coli and Saccharomyces cerevisiae Strains for Robust Manufacturing

As your reliable CDMO partner, we pride ourselves on our track record of over 84 proteins successfully expressed and manufactured in a microbial environment since 2011. Leverage our expertise in strain development to identify and further develop high-quality E.coli and Saccharomyces cerevisiae strains that provide excellent expression at manufacturing scales.

Setting a Strong Foundation for Microbial Manufacturing

A robust manufacturing process begins with the thoughtful development of the ideal strain. Strain development is an extremely important aspect of successful GMP manufacturing as it will provide critical information regarding scale-up activities, expected yields, product characteristics, and subsequent process unit operations.

When you partner with Cytovance, you gain access to our deep experience in strain development and our innovative KeystoneTM Expression System for jumpstarting any E.coli-based programs. The KeystoneTM Expression System enables unrivaled control over the manufacturing process from the start and the freedom to operate without royalties.

Strain Development Done Right

For E.coli-based production, our clients will have access to the Keystone^TM Expression System, which offers unrivaled solutions to create productive and robust manufacturing strains. This novel approach developed by Cytovance gives our clients the highest chance of success in manufacturing by creating and subsequently evaluating the performance of multiple strains simultaneously in scaled-down batch and fed-batch formats. To complement this system, our experienced analytical teams leverage the Sartorius Ambr^® 250 fully automated, high-throughput bioreactor system to manage multiple experiments while reducing the final cost per experiment.

Streamline Development Costs

Cytovance’s expertly executed strain development services represent an attractive strategy for early risk mitigation in microbial programs. The identification of robust manufacturing strains can significantly reduce project costs and timelines associated with subsequent and potentially drawn-out process development activities.

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Strain Development​